Metaanalysis of Methylenetetrahydrofolate Reductase (MTHFR) Polymorphisms Affecting Methotrexate Toxicity
نویسندگان
چکیده
منابع مشابه
Association of Methylenetetrahydrofolate Reductase (MTHFR) Gene C677T and A1298C Polymorphisms with Myocardial Infarction From North of Fars Province
Background: The association between Methylene tetrahydrofolate reductase polymorphism and Coronary Artery diseases risk has been both confirmed and refuted in a number of published studies. The aim of this study was to investigate whether genetic polymorphisms of MTHFR (C677T, A1298C) contributed to the development of myocardial infarction (MI). Materials and Methods: The present case-contro...
متن کاملAttribution of posttransplantation toxicity to methotrexate regarding genotype of methylenetetrahydrofolate reductase gene (MTHFR) polymorphism needs further clarification.
We thank Drs Djulbegovic and Cohen for their comments on our recently published study.1 As they point out, we estimated the rate of fatal hemorrhage for patients with refractory idiopathic thrombocytopenic purpura (ITP) at 0.019 cases per patient-year at risk (where time at risk was defined as time with fewer than 30 3 109/L platelets), using a method previously described by Cohen et al.2 Unfor...
متن کاملMethylenetetrahydrofolate Reductase Polymorphisms in Iranian Patients with Glanzmann’s Thrombasthenia
Background: The most common polymorphisms identified in the Methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C lead to defective activity of this enzyme and increase the risk of venous and arterial thrombosis. There are limited investigations regarding the effects of thrombogenic polymorphisms on the clinical phenotypes of rare hereditary hemorrhagic disorders like Glanzmann's t...
متن کاملCorrelation Between Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphisms and Pemetrexed Chemotherapy Efficacy/Toxicity in Non-Squamous Non-Small Cell Lung Cancer
BACKGROUND In the present study, we aimed to retrospectively analyze the correlation between toxicity of pemetrexed (PEM) chemotherapy and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms in patients with advanced non-squamous non-small cell lung cancer (non-sq NSCLC). MATERIAL AND METHODS We used polymerase chain reaction, gene scanning, and restriction fragment length polymorph...
متن کاملMethylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia.
Low folate intake as well as alterations in folate metabolism as a result of polymorphisms in the enzyme methylenetetrahydrofolate reductase (MTHFR) have been associated with an increased incidence of neural tube defects, vascular disease, and some cancers. Polymorphic variants of MTHFR lead to enhanced thymidine pools and better quality DNA synthesis that could afford some protection from the ...
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ژورنال
عنوان ژورنال: The Journal of Rheumatology
سال: 2009
ISSN: 0315-162X,1499-2752
DOI: 10.3899/jrheum.080576